Cyclizine vs Cinnarizine – Which One Should You Choose?
If you’ve ever felt dizzy on a boat or after a night out, chances are a doctor mentioned cyclizine or cinnarizine. Both are antihistamines that calm the inner ear, but they aren’t identical. Knowing how they differ can save you from unwanted side effects and help you pick the right pill for your situation.
How They Work and When They’re Used
Cyclizine blocks histamine receptors in the brain, which reduces nausea and the feeling of motion sickness. It’s a go‑to for travelers, chemotherapy patients, or anyone who gets queasy on a short trip. Cinnarizine does a similar job but also has calcium‑channel blocking properties that make it useful for vertigo caused by inner‑ear problems. Because of this extra action, doctors sometimes prescribe cinnarizine for chronic balance disorders rather than just occasional travel sickness.
Both drugs come in tablet form, and the effect kicks in within 30 to 60 minutes. Cyclizine typically lasts about 4–6 hours, so you might need a second dose for long journeys. Cinnarizine’s effects stretch a bit longer—up to 8 hours—making it handy for full‑day activities.
Side Effects, Dosage & Safety Tips
The most common complaint with cyclizine is drowsiness. Some people feel a mild dry mouth or headache, but these usually fade after the first dose. Cinnarizine can cause similar sleepiness, plus occasional weight gain if you take it for months. Both medicines may make you less alert, so avoid driving or operating heavy machinery until you know how they affect you.
Typical adult doses are 50 mg of cyclizine once or twice daily, and 75 mg of cinnarizine once a day (often at night). Kids under 12 usually aren’t given these drugs without special supervision. Always follow your doctor’s exact instructions—over‑using can lead to stronger sedation or even low blood pressure.
If you have liver disease, glaucoma, or a history of heart problems, talk to a pharmacist before starting either medication. Alcohol amplifies drowsiness, so keep drinks minimal while on treatment. Pregnant or breastfeeding women should check with their doctor because safety data are limited.
In practice, choose cyclizine for short trips or when you need fast relief from nausea. Pick cinnarizine if you struggle with ongoing vertigo or need a longer‑lasting effect. Both work well for motion sickness; the decision often comes down to how long you need coverage and which side effects bother you more.
Bottom line: both drugs are affordable, widely available, and effective when used correctly. Read the label, start with the lowest dose that controls your symptoms, and give yourself a day or two to see how you feel before adjusting. If problems persist, a quick call to your doctor can fine‑tune the choice.

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